Ingestible Capsule Advances May Lead to Earlier Detection of Diseases

MSAL alumni Brian Holt, Dr. Justin Stine, and Dr. Luke Beardslee and other University of Maryland-affiliated (UMD) researchers have made important progress in developing an ingestible capsule with non-invasive bioimpedance sensing that can identify the "leaky gut" precursors of many gastrointestinal (GI) tract conditions. A new invited paper detailing the research, "An ingestible bioimpedance sensing device for wireless monitoring of epithelial barriers," has been published in the Feb. 7, 2025 edition of the Nature journal, Microsystems and Nanoengineering.

The paper was written by Brian Holt, Justin Stine, Luke Beardslee, Hammed Ayansola, Younggeon Jin, Pankaj Pasricha, and Reza Ghodssi. Holt, who earned an M.S. degree at UMD in 2024, is currently a cyber software engineer at Lockheed Martin. Stine is a UMD Assistant Research Scientist at the MATRIX Lab in California, Md. Beardslee is affiliated with the UMD Institute for Systems Research. Ayansola is a Ph.D. student and Jin is an assistant professor in the UMD Department of Animal and Avian Sciences. Pasricha, a physician and researcher specializing in gastroenterology and neurogastroenterology, is director of medicine to the Division of Gastroenterology and Hepatology and Department of Internal Medicine at the Mayo Clinic in Phoenix, Ariz. Ghodssi is a UMD professor with a joint appointment in the Department of Electrical and Computer Engineering and the Institute for Systems Research at the University of Maryland. He is Research Director for the MATRIX Lab and Director of the Microsensors and Actuators Lab. He was the graduate advisor to Holt and Stine.

More information can be found on the MATRIX Lab News (11 - February / 2025)